Drug interactions
Darunavir + Miglitol
Severity: Moderate
Darunavir and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, may be associated with insulin resistance and hyperglycemia. This could reduce the glycemic benefit of miglitol.
What this interaction means in plain words
Darunavir and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Miglitol belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-related insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting darunavir. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Miglitol?
MediHelp rates the interaction as moderate. Darunavir and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, may be associated with insulin resistance and hyperglycemia. This could reduce the glycemic benefit of miglitol.
How serious is the interaction between Darunavir and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting darunavir. Adjust antidiabetic therapy as needed.
What other medicines interact with Miglitol?
MediHelp also lists interactions of Miglitol with, for example, Pramlintide, Aripiprazole, Asenapine. The full list is on the Miglitol page.
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