Drug interactions
Dopamine + Opicapone
Severity: Moderate
Dopamine and Opicapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone inhibits COMT, an enzyme that contributes to catecholamine breakdown, so exposure to dopamine given intravenously may be prolonged. This can intensify its cardiovascular effects, including tachycardia, arrhythmia and blood pressure changes.
What this interaction means in plain words
Dopamine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Opicapone belongs to Central Nervous System.
Why it happens
Inhibition of COMT-mediated catecholamine metabolism.
What to do
Monitor heart rate, rhythm and blood pressure, and start dopamine at a low dose with cautious titration in patients taking opicapone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
Frequently asked questions
Can I take Dopamine with Opicapone?
MediHelp rates the interaction as moderate. Dopamine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opicapone inhibits COMT, an enzyme that contributes to catecholamine breakdown, so exposure to dopamine given intravenously may be prolonged. This can intensify its cardiovascular effects, including tachycardia, arrhythmia and blood pressure changes.
How serious is the interaction between Dopamine and Opicapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and start dopamine at a low dose with cautious titration in patients taking opicapone.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Selegiline transdermal. The full list is on the Dopamine page.
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