Drug interactions
Asenapine + Perampanel
Severity: Moderate
Asenapine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can increase drowsiness, dizziness and impaired psychomotor performance. Perampanel can also cause irritability and aggression, which may complicate psychiatric treatment.
What this interaction means in plain words
Asenapine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects (pharmacodynamic).
What to do
Monitor for excess sedation, dizziness and falls, particularly during dose titration of either drug. Advise patients to avoid driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Bosentan + Perampanel Moderate
Frequently asked questions
Can I take Asenapine with Perampanel?
MediHelp rates the interaction as moderate. Asenapine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can increase drowsiness, dizziness and impaired psychomotor performance. Perampanel can also cause irritability and aggression, which may complicate psychiatric treatment.
How serious is the interaction between Asenapine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and falls, particularly during dose titration of either drug. Advise patients to avoid driving until the combined effect is known.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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