Drug interactions
Amobarbital + Perampanel
Severity: Moderate
Amobarbital and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing antiepileptics and barbiturates lower perampanel concentrations, potentially reducing seizure control. Both drugs also cause CNS depression, adding sedation and dizziness.
What this interaction means in plain words
Amobarbital and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
CYP3A4 induction by amobarbital increases perampanel clearance, plus additive CNS depression.
What to do
Monitor seizure control and sedation, and titrate perampanel to response. Adjust the dose again if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Asenapine + Perampanel Moderate
- Bosentan + Perampanel Moderate
Frequently asked questions
Can I take Amobarbital with Perampanel?
MediHelp rates the interaction as moderate. Amobarbital and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing antiepileptics and barbiturates lower perampanel concentrations, potentially reducing seizure control. Both drugs also cause CNS depression, adding sedation and dizziness.
How serious is the interaction between Amobarbital and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and titrate perampanel to response. Adjust the dose again if the barbiturate is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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