Drug interactions
Amisulpride + Perampanel
Severity: Moderate
Amisulpride and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel commonly causes dizziness, somnolence and gait disturbance, and amisulpride can add to sedation. Perampanel can also cause psychiatric adverse effects such as irritability and aggression, which matter in patients with psychiatric illness.
What this interaction means in plain words
Amisulpride and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation, balance and mood or behavior changes, and counsel about driving. Adjust doses if impairment is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
- Bosentan + Perampanel Moderate
Frequently asked questions
Can I take Amisulpride with Perampanel?
MediHelp rates the interaction as moderate. Amisulpride and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel commonly causes dizziness, somnolence and gait disturbance, and amisulpride can add to sedation. Perampanel can also cause psychiatric adverse effects such as irritability and aggression, which matter in patients with psychiatric illness.
How serious is the interaction between Amisulpride and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, balance and mood or behavior changes, and counsel about driving. Adjust doses if impairment is significant.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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