Drug interactions
Asenapine + Pregabalin
Severity: Moderate
Asenapine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and asenapine both cause somnolence and dizziness, and combined use can intensify sedation and impair coordination and cognition. Respiratory depression is a concern mainly with other CNS depressants or in vulnerable patients.
What this interaction means in plain words
Asenapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for oversedation and falls, especially in older adults or those with respiratory disease. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Asenapine with Pregabalin?
MediHelp rates the interaction as moderate. Asenapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin and asenapine both cause somnolence and dizziness, and combined use can intensify sedation and impair coordination and cognition. Respiratory depression is a concern mainly with other CNS depressants or in vulnerable patients.
How serious is the interaction between Asenapine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, especially in older adults or those with respiratory disease. Use the lowest effective doses.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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