Drug interactions
Asenapine + Triclabendazole
Severity: Moderate
Asenapine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so their combination may add to the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Asenapine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation through cardiac repolarization effects (potassium channel blockade).
What to do
Obtain a baseline ECG if the patient has risk factors and correct potassium and magnesium before treatment. Because triclabendazole is given for a short course, consider monitoring ECG during therapy in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Asenapine with Triclabendazole?
MediHelp rates the interaction as moderate. Asenapine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so their combination may add to the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Asenapine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG if the patient has risk factors and correct potassium and magnesium before treatment. Because triclabendazole is given for a short course, consider monitoring ECG during therapy in high-risk patients.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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