Drug interactions
Asenapine + Valbenazine
Severity: Moderate
Asenapine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures and asenapine also has QT-prolonging potential. Together they may increase arrhythmia risk, particularly in patients with cardiac risk factors or reduced valbenazine clearance.
What this interaction means in plain words
Asenapine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation; valbenazine additionally causes VMAT2 inhibition with sedating effects that may add to asenapine.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor for syncope or palpitations. Avoid additional QT-prolonging drugs and review valbenazine dose in poor CYP2D6 metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Valbenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Asenapine with Valbenazine?
MediHelp rates the interaction as moderate. Asenapine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures and asenapine also has QT-prolonging potential. Together they may increase arrhythmia risk, particularly in patients with cardiac risk factors or reduced valbenazine clearance.
How serious is the interaction between Asenapine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor for syncope or palpitations. Avoid additional QT-prolonging drugs and review valbenazine dose in poor CYP2D6 metabolizers.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
