Drug interactions
Asenapine transdermal + Chlorpromazine
Severity: Major
Asenapine transdermal and Chlorpromazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics that can prolong the QT interval, so combining them increases the risk of ventricular arrhythmias. Additive sedation, orthostatic hypotension and extrapyramidal effects are also likely.
What this interaction means in plain words
Asenapine transdermal and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and overlapping dopamine, histamine and adrenergic receptor blockade.
What to do
Avoid using two antipsychotics together; consolidate to a single agent. If combined temporarily, monitor ECG, electrolytes and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Chlorpromazine?
MediHelp rates the interaction as major. Asenapine transdermal and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are antipsychotics that can prolong the QT interval, so combining them increases the risk of ventricular arrhythmias. Additive sedation, orthostatic hypotension and extrapyramidal effects are also likely.
How serious is the interaction between Asenapine transdermal and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antipsychotics together; consolidate to a single agent. If combined temporarily, monitor ECG, electrolytes and blood pressure.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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