Drug interactions
Asenapine transdermal + Prochlorperazine
Severity: Major
Asenapine transdermal and Prochlorperazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics with dopamine-blocking activity, and both can prolong QT and cause sedation. Together they increase the risk of arrhythmia, extrapyramidal symptoms and excessive sedation.
What this interaction means in plain words
Asenapine transdermal and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive D2 receptor antagonism, QT prolongation and CNS depression.
What to do
Avoid concurrent use where possible. If necessary, monitor ECG and electrolytes, and watch for movement disorders and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Almus Migraine Relief 3mg Buccal Tablets - SmPC sections 4.3/4.5 (class statement: other antipsychotics; "There is an increased risk of arrhythmias when neuroleptics are used with concomitant QT prolonging drugs (including certain anti-arrhythmics, antidepressants, ") — electronic medicines compendium (UK SmPC)
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Asenapine transdermal with Prochlorperazine?
MediHelp rates the interaction as major. Asenapine transdermal and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are antipsychotics with dopamine-blocking activity, and both can prolong QT and cause sedation. Together they increase the risk of arrhythmia, extrapyramidal symptoms and excessive sedation.
How serious is the interaction between Asenapine transdermal and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If necessary, monitor ECG and electrolytes, and watch for movement disorders and sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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