Drug interactions
Aspirin / citric acid / sodium bicarbonate + Lisdexamfetamine
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The bicarbonate and citrate content can alkalinize the urine, reducing renal elimination of amphetamine. This may increase and prolong exposure to the active metabolite of lisdexamfetamine and raise the risk of stimulant adverse effects.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Urinary alkalinization increases the non-ionized fraction of dextroamphetamine, enhancing tubular reabsorption and reducing clearance.
What to do
Monitor heart rate, blood pressure and signs of overstimulation if the antacid is used regularly. Reduce the lisdexamfetamine dose if needed or separate to occasional use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The bicarbonate and citrate content can alkalinize the urine, reducing renal elimination of amphetamine. This may increase and prolong exposure to the active metabolite of lisdexamfetamine and raise the risk of stimulant adverse effects.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and signs of overstimulation if the antacid is used regularly. Reduce the lisdexamfetamine dose if needed or separate to occasional use.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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