Drug interactions
Astragalus + Leflunomide
Severity: Minor
Astragalus and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Astragalus has immunostimulant properties that could theoretically oppose the immunosuppressive effect of leflunomide. Clinical data are lacking and the effect is uncertain.
What this interaction means in plain words
Astragalus and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition through immune stimulation; not clearly established.
What to do
Advise patients to avoid astragalus supplements while on leflunomide, and monitor disease activity if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Astragalus with Leflunomide?
MediHelp rates the interaction as minor. Astragalus and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Astragalus has immunostimulant properties that could theoretically oppose the immunosuppressive effect of leflunomide. Clinical data are lacking and the effect is uncertain.
How serious is the interaction between Astragalus and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid astragalus supplements while on leflunomide, and monitor disease activity if used.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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