Drug interactions
Atazanavir + Bortezomib
Severity: Moderate
Atazanavir and Bortezomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and may raise bortezomib exposure. Higher levels may worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Atazanavir and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Bortezomib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated bortezomib metabolism.
What to do
Monitor for neuropathy, cytopenias and gastrointestinal effects. Consider bortezomib dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Bortezomib?
MediHelp rates the interaction as moderate. Atazanavir and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a strong CYP3A4 inhibitor and may raise bortezomib exposure. Higher levels may worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Atazanavir and Bortezomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, cytopenias and gastrointestinal effects. Consider bortezomib dose reduction if toxicity emerges.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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