Drug interactions
Atazanavir + Cinacalcet
Severity: Moderate
Atazanavir and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise cinacalcet concentrations. Because cinacalcet has multiple clearance pathways, the increase is modest but may enhance hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Atazanavir and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Cinacalcet belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated cinacalcet metabolism.
What to do
Monitor serum calcium and PTH after starting or stopping atazanavir. Reduce cinacalcet dose if hypocalcemia or intolerance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Cinacalcet?
MediHelp rates the interaction as moderate. Atazanavir and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may raise cinacalcet concentrations. Because cinacalcet has multiple clearance pathways, the increase is modest but may enhance hypocalcemia and gastrointestinal effects.
How serious is the interaction between Atazanavir and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping atazanavir. Reduce cinacalcet dose if hypocalcemia or intolerance occurs.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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