Drug interactions
Atazanavir + Clorazepate
Severity: Moderate
Atazanavir and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir may raise concentrations of clorazepate's active metabolite, nordiazepam, and cause stronger or longer sedation. Respiratory depression is a concern at higher doses or in vulnerable patients.
What this interaction means in plain words
Atazanavir and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Clorazepate belongs to Central Nervous System.
Why it happens
Atazanavir inhibits CYP3A4, which contributes to the metabolism of clorazepate's active metabolite.
What to do
Monitor for oversedation and reduce the clorazepate dose if needed. Consider a benzodiazepine not dependent on CYP3A4, such as lorazepam, if problems persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Clorazepate?
MediHelp rates the interaction as moderate. Atazanavir and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir may raise concentrations of clorazepate's active metabolite, nordiazepam, and cause stronger or longer sedation. Respiratory depression is a concern at higher doses or in vulnerable patients.
How serious is the interaction between Atazanavir and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the clorazepate dose if needed. Consider a benzodiazepine not dependent on CYP3A4, such as lorazepam, if problems persist.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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