Drug interactions
Atazanavir + Crizotinib
Severity: Major
Atazanavir and Crizotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise crizotinib concentrations, while crizotinib may in turn raise atazanavir levels. Both drugs can prolong the PR or QT interval and cause bradycardia, so exposure increases may add to cardiac toxicity and hepatotoxicity.
What this interaction means in plain words
Atazanavir and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Crizotinib belongs to Oncology.
Why it happens
Mutual CYP3A4 inhibition, with additive effects on cardiac conduction.
What to do
Avoid the combination if possible; otherwise monitor ECG, heart rate and liver tests, and consider reducing the crizotinib dose per labeling if a strong CYP3A inhibitor is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Crizotinib?
MediHelp rates the interaction as major. Atazanavir and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and can raise crizotinib concentrations, while crizotinib may in turn raise atazanavir levels. Both drugs can prolong the PR or QT interval and cause bradycardia, so exposure increases may add to cardiac toxicity and hepatotoxicity.
How serious is the interaction between Atazanavir and Crizotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG, heart rate and liver tests, and consider reducing the crizotinib dose per labeling if a strong CYP3A inhibitor is required.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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