Drug interactions
Atazanavir + Dapsone
Severity: Minor
Atazanavir and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise dapsone concentrations. This could increase dose-related adverse effects such as hemolysis and methemoglobinemia, though the effect is probably modest.
What this interaction means in plain words
Atazanavir and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Dapsone belongs to Anti Bacterial.
Why it happens
Atazanavir inhibits CYP3A4, reducing the oxidative metabolism of dapsone.
What to do
Monitor for hemolysis, methemoglobinemia and anemia, especially in G6PD-deficient patients. Reduce the dapsone dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Dapsone?
MediHelp rates the interaction as minor. Atazanavir and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and may raise dapsone concentrations. This could increase dose-related adverse effects such as hemolysis and methemoglobinemia, though the effect is probably modest.
How serious is the interaction between Atazanavir and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hemolysis, methemoglobinemia and anemia, especially in G6PD-deficient patients. Reduce the dapsone dose if toxicity appears.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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