Drug interactions
Atazanavir + Darunavir
Severity: Moderate
Atazanavir and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two protease inhibitors offers no established dosing and may alter exposure of either drug. Overlapping toxicities and unpredictable levels make the combination undesirable.
What this interaction means in plain words
Atazanavir and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Darunavir belongs to Anti Virals.
Why it happens
Competitive CYP3A4 metabolism and transporter interactions between protease inhibitors alter plasma concentrations unpredictably.
What to do
Avoid dual protease inhibitor therapy; choose a regimen with a single protease inhibitor. If used, monitor viral load, drug levels and bilirubin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Darunavir?
MediHelp rates the interaction as moderate. Atazanavir and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two protease inhibitors offers no established dosing and may alter exposure of either drug. Overlapping toxicities and unpredictable levels make the combination undesirable.
How serious is the interaction between Atazanavir and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dual protease inhibitor therapy; choose a regimen with a single protease inhibitor. If used, monitor viral load, drug levels and bilirubin.
What other medicines interact with Darunavir?
MediHelp also lists interactions of Darunavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Darunavir page.
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