Drug interactions
Atazanavir + Dasatinib
Severity: Major
Atazanavir and Dasatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can markedly raise dasatinib concentrations. This increases the risk of myelosuppression, fluid retention, pleural effusion and QT prolongation.
What this interaction means in plain words
Atazanavir and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Dasatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by atazanavir reduces dasatinib clearance.
What to do
Use a non-inhibiting antiretroviral where possible. If it is unavoidable, consider reducing the dasatinib dose and monitor blood counts, ECG and fluid status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Dasatinib?
MediHelp rates the interaction as major. Atazanavir and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can markedly raise dasatinib concentrations. This increases the risk of myelosuppression, fluid retention, pleural effusion and QT prolongation.
How serious is the interaction between Atazanavir and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inhibiting antiretroviral where possible. If it is unavoidable, consider reducing the dasatinib dose and monitor blood counts, ECG and fluid status.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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