Drug interactions
Atazanavir + Eluxadoline
Severity: Moderate
Atazanavir and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits hepatic OATP1B1 uptake and raises eluxadoline exposure. Higher levels increase the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Atazanavir and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline increases systemic concentrations.
What to do
Reduce eluxadoline to 75 mg twice daily during co-administration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eluxadoline
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Eluxadoline?
MediHelp rates the interaction as moderate. Atazanavir and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits hepatic OATP1B1 uptake and raises eluxadoline exposure. Higher levels increase the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Atazanavir and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily during co-administration. Monitor for constipation, abdominal pain and signs of pancreatitis.
What other medicines interact with Eluxadoline?
MediHelp also lists interactions of Eluxadoline with, for example, Alosetron, Atropine, Buprenorphine. The full list is on the Eluxadoline page.
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