Drug interactions
Atazanavir + Etonogestrel
Severity: Moderate
Atazanavir and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise progestin concentrations, which may increase progestogenic adverse effects. Contraceptive efficacy is not expected to fall, so the concern is mostly tolerability.
What this interaction means in plain words
Atazanavir and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Etonogestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of etonogestrel by atazanavir (boosted with ritonavir or cobicistat in practice).
What to do
Monitor for progestin-related adverse effects such as bleeding changes, mood changes and metabolic effects; the implant can be continued if tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Etonogestrel?
MediHelp rates the interaction as moderate. Atazanavir and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise progestin concentrations, which may increase progestogenic adverse effects. Contraceptive efficacy is not expected to fall, so the concern is mostly tolerability.
How serious is the interaction between Atazanavir and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin-related adverse effects such as bleeding changes, mood changes and metabolic effects; the implant can be continued if tolerated.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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