Drug interactions
Atazanavir + Etravirine
Severity: Moderate
Atazanavir and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine lowers dolutegravir exposure, while boosted atazanavir offsets this. Unboosted atazanavir is not recommended with etravirine because etravirine reduces atazanavir levels.
What this interaction means in plain words
Atazanavir and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and UGT1A1, lowering concentrations of atazanavir and dolutegravir.
What to do
Use atazanavir only with ritonavir or cobicistat when combined with etravirine. Avoid unboosted atazanavir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Etravirine?
MediHelp rates the interaction as moderate. Atazanavir and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine lowers dolutegravir exposure, while boosted atazanavir offsets this. Unboosted atazanavir is not recommended with etravirine because etravirine reduces atazanavir levels.
How serious is the interaction between Atazanavir and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use atazanavir only with ritonavir or cobicistat when combined with etravirine. Avoid unboosted atazanavir.
What other medicines interact with Etravirine?
MediHelp also lists interactions of Etravirine with, for example, Efavirenz, Isavuconazole, Amobarbital. The full list is on the Etravirine page.
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