Drug interactions
Atazanavir + Labetalol
Severity: Moderate
Atazanavir and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir can prolong the PR interval and cause AV conduction delay. Combined with labetalol, which slows AV nodal conduction and heart rate, there is a risk of bradycardia, AV block and hypotension.
What this interaction means in plain words
Atazanavir and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Labetalol belongs to Cardiovascular.
Why it happens
Additive effects on AV nodal conduction; atazanavir PR prolongation combined with beta-blockade.
What to do
Monitor heart rate, blood pressure and ECG, especially PR interval, at initiation. Reduce the labetalol dose if symptomatic bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Labetalol?
MediHelp rates the interaction as moderate. Atazanavir and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir can prolong the PR interval and cause AV conduction delay. Combined with labetalol, which slows AV nodal conduction and heart rate, there is a risk of bradycardia, AV block and hypotension.
How serious is the interaction between Atazanavir and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially PR interval, at initiation. Reduce the labetalol dose if symptomatic bradycardia or conduction delay occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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