Drug interactions
Dacomitinib + Omeprazole
Severity: Major
Dacomitinib and Omeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole lowers dacomitinib concentrations, which may reduce its antitumour efficacy. Dacomitinib absorption depends on gastric acidity.
What this interaction means in plain words
Dacomitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces dacomitinib solubility and absorption.
What to do
Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or an H2 antagonist, dosing dacomitinib at least 6 hours before or 10 hours after the H2 blocker.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Omeprazole?
MediHelp rates the interaction as major. Dacomitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omeprazole lowers dacomitinib concentrations, which may reduce its antitumour efficacy. Dacomitinib absorption depends on gastric acidity.
How serious is the interaction between Dacomitinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or an H2 antagonist, dosing dacomitinib at least 6 hours before or 10 hours after the H2 blocker.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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