Drug interactions
Atazanavir + Solifenacin
Severity: Moderate
Atazanavir and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and raises solifenacin exposure, increasing anticholinergic effects and the dose-related risk of QT prolongation. Atazanavir itself can prolong the PR interval.
What this interaction means in plain words
Atazanavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated solifenacin metabolism by atazanavir.
What to do
Limit solifenacin to 5 mg daily with strong CYP3A4 inhibitors or boosted regimens and monitor for anticholinergic effects and ECG changes when risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Solifenacin?
MediHelp rates the interaction as moderate. Atazanavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and raises solifenacin exposure, increasing anticholinergic effects and the dose-related risk of QT prolongation. Atazanavir itself can prolong the PR interval.
How serious is the interaction between Atazanavir and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily with strong CYP3A4 inhibitors or boosted regimens and monitor for anticholinergic effects and ECG changes when risk factors exist.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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