Drug interactions
Atenolol-chlorthalidone + Avanafil
Severity: Moderate
Atenolol-chlorthalidone and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a vasodilator that lowers blood pressure, and the effect adds to that of atenolol and chlorthalidone. Symptomatic hypotension, dizziness or syncope may occur, particularly at treatment initiation.
What this interaction means in plain words
Atenolol-chlorthalidone and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation and blood pressure lowering from PDE5 inhibition combined with beta-blockade and diuresis.
What to do
Ensure blood pressure is stable before starting avanafil, begin at a lower dose, and counsel on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Avanafil?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a vasodilator that lowers blood pressure, and the effect adds to that of atenolol and chlorthalidone. Symptomatic hypotension, dizziness or syncope may occur, particularly at treatment initiation.
How serious is the interaction between Atenolol-chlorthalidone and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is stable before starting avanafil, begin at a lower dose, and counsel on orthostatic symptoms.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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