Drug interactions
Atenolol-chlorthalidone + Calcifediol
Severity: Moderate
Atenolol-chlorthalidone and Calcifediol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone reduces urinary calcium excretion, and combined with calcifediol, which raises calcium absorption, this can cause hypercalcaemia. Symptoms include nausea, confusion, polyuria and, in severe cases, arrhythmias or renal impairment.
What this interaction means in plain words
Atenolol-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
Why it happens
Thiazide-type diuretics increase renal calcium reabsorption while vitamin D increases intestinal calcium absorption, giving additive hypercalcaemia.
What to do
Monitor serum calcium and renal function, especially at initiation and after dose changes. Reduce the calcifediol dose or stop the diuretic if hypercalcaemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
- Calcifediol + Captopril-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Calcifediol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone reduces urinary calcium excretion, and combined with calcifediol, which raises calcium absorption, this can cause hypercalcaemia. Symptoms include nausea, confusion, polyuria and, in severe cases, arrhythmias or renal impairment.
How serious is the interaction between Atenolol-chlorthalidone and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, especially at initiation and after dose changes. Reduce the calcifediol dose or stop the diuretic if hypercalcaemia develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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