Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Calcifediol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and calcifediol increases calcium absorption, so together they can cause hypercalcemia. This is especially relevant in patients with renal impairment, hyperparathyroidism or high calcium intake.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
Why it happens
Thiazide-enhanced renal calcium reabsorption combined with vitamin D-driven intestinal calcium absorption.
What to do
Monitor serum calcium and renal function periodically, and reduce the vitamin D or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Calcifediol
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcifediol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and calcifediol increases calcium absorption, so together they can cause hypercalcemia. This is especially relevant in patients with renal impairment, hyperparathyroidism or high calcium intake.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, and reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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