Drug interactions
Atenolol-chlorthalidone + Disopyramide
Severity: Major
Atenolol-chlorthalidone and Disopyramide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide has strong negative inotropic and conduction-slowing effects. With atenolol, there is a risk of bradycardia, AV block, hypotension and worsened heart failure, and chlorthalidone-induced hypokalemia can increase proarrhythmic risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Disopyramide belongs to Cardiovascular.
Why it happens
Additive negative inotropic and chronotropic effects, with electrolyte disturbance from the diuretic potentiating arrhythmia.
What to do
Avoid in patients with left ventricular dysfunction or conduction disease; otherwise monitor ECG, blood pressure and potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atenolol-chlorthalidone
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Disopyramide?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide has strong negative inotropic and conduction-slowing effects. With atenolol, there is a risk of bradycardia, AV block, hypotension and worsened heart failure, and chlorthalidone-induced hypokalemia can increase proarrhythmic risk.
How serious is the interaction between Atenolol-chlorthalidone and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with left ventricular dysfunction or conduction disease; otherwise monitor ECG, blood pressure and potassium closely.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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