Drug interactions
Atogepant + Ciprofloxacin
Severity: Moderate
Atogepant and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a moderate CYP3A4 inhibitor and may increase atogepant exposure. This could raise the risk of atogepant adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated atogepant metabolism.
What to do
Monitor for atogepant adverse effects during ciprofloxacin therapy. Review atogepant dose in patients with other interacting factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Ciprofloxacin?
MediHelp rates the interaction as moderate. Atogepant and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin is a moderate CYP3A4 inhibitor and may increase atogepant exposure. This could raise the risk of atogepant adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for atogepant adverse effects during ciprofloxacin therapy. Review atogepant dose in patients with other interacting factors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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