Drug interactions
Atogepant + Fluoxetine
Severity: Minor
Atogepant and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is metabolized mainly by CYP3A4, and fluoxetine is a weak CYP3A4 inhibitor through norfluoxetine. Only a small rise in atogepant exposure is expected and is unlikely to matter for most patients.
What this interaction means in plain words
Atogepant and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Fluoxetine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated atogepant metabolism.
What to do
No dose adjustment is generally required. Monitor tolerability, especially constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Fluoxetine?
MediHelp rates the interaction as minor. Atogepant and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is metabolized mainly by CYP3A4, and fluoxetine is a weak CYP3A4 inhibitor through norfluoxetine. Only a small rise in atogepant exposure is expected and is unlikely to matter for most patients.
How serious is the interaction between Atogepant and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor tolerability, especially constipation and nausea.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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