Drug interactions
Atogepant + Imatinib
Severity: Moderate
Atogepant and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor that may increase atogepant levels. Adverse effects such as constipation, nausea and fatigue may be more frequent.
What this interaction means in plain words
Atogepant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4 and reduces atogepant first-pass and systemic metabolism.
What to do
Limit atogepant to the lower dose recommended for CYP3A4 inhibitors when used for chronic migraine prevention, and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atogepant and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Imatinib?
MediHelp rates the interaction as moderate. Atogepant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atogepant is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor that may increase atogepant levels. Adverse effects such as constipation, nausea and fatigue may be more frequent.
How serious is the interaction between Atogepant and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the lower dose recommended for CYP3A4 inhibitors when used for chronic migraine prevention, and monitor tolerability.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
