Drug interactions
Atogepant + Methoxsalen
Severity: Minor
Atogepant and Methoxsalen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is cleared mainly by CYP3A4, and methoxsalen can inhibit CYP enzymes, which may raise atogepant exposure. Higher levels could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition by methoxsalen reducing atogepant clearance.
What to do
No routine adjustment is needed. Monitor tolerability and consider a lower atogepant dose if adverse effects arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Methoxsalen?
MediHelp rates the interaction as minor. Atogepant and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is cleared mainly by CYP3A4, and methoxsalen can inhibit CYP enzymes, which may raise atogepant exposure. Higher levels could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Methoxsalen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor tolerability and consider a lower atogepant dose if adverse effects arise.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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