Drug interactions
Atogepant + Mifepristone
Severity: Moderate
Atogepant and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a strong CYP3A4 inhibitor and can raise atogepant plasma concentrations. Higher exposure may increase dose-related adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of atogepant by mifepristone.
What to do
Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors (10 mg once daily for migraine prevention). Monitor for increased adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Mifepristone?
MediHelp rates the interaction as moderate. Atogepant and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is a strong CYP3A4 inhibitor and can raise atogepant plasma concentrations. Higher exposure may increase dose-related adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors (10 mg once daily for migraine prevention). Monitor for increased adverse effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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