Drug interactions
Atogepant + Nicardipine
Severity: Minor
Atogepant and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak CYP3A4 inhibitor and could modestly increase atogepant exposure. A clinically important effect is unlikely.
What this interaction means in plain words
Atogepant and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated atogepant metabolism by nicardipine.
What to do
No dose adjustment is usually needed. Watch for constipation, nausea and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Nicardipine?
MediHelp rates the interaction as minor. Atogepant and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak CYP3A4 inhibitor and could modestly increase atogepant exposure. A clinically important effect is unlikely.
How serious is the interaction between Atogepant and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for constipation, nausea and fatigue.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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