Drug interactions
Atogepant + Quinidine
Severity: Minor
Atogepant and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a P-gp inhibitor and weak CYP3A4 inhibitor, so it could modestly raise atogepant exposure. The expected rise is small and atogepant has a wide margin of tolerability, so clinical consequences are probably limited to more headache-drug adverse effects such as constipation or nausea.
What this interaction means in plain words
Atogepant and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine may weakly inhibit CYP3A4 and P-gp, reducing the clearance of atogepant.
What to do
No routine dose change is needed; monitor for atogepant adverse effects such as constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Quinidine?
MediHelp rates the interaction as minor. Atogepant and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine is a P-gp inhibitor and weak CYP3A4 inhibitor, so it could modestly raise atogepant exposure. The expected rise is small and atogepant has a wide margin of tolerability, so clinical consequences are probably limited to more headache-drug adverse effects such as constipation or nausea.
How serious is the interaction between Atogepant and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for atogepant adverse effects such as constipation and nausea.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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