Drug interactions
Atogepant + Rifampicin
Severity: Moderate
Atogepant and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin reduces atogepant exposure, which may reduce its migraine preventive efficacy.
What this interaction means in plain words
Atogepant and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and possibly OATP transporter effects reduce atogepant exposure.
What to do
Use the labeled adjusted atogepant dose during rifampicin therapy. Monitor migraine frequency regularly for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atogepant and Rifampicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Atogepant with Rifampicin?
MediHelp rates the interaction as moderate. Atogepant and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin reduces atogepant exposure, which may reduce its migraine preventive efficacy.
How serious is the interaction between Atogepant and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled adjusted atogepant dose during rifampicin therapy. Monitor migraine frequency regularly for loss of efficacy.
What other medicines interact with Atogepant?
MediHelp also lists interactions of Atogepant with, for example, Amobarbital, Apalutamide, Aprepitant. The full list is on the Atogepant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
