Drug interactions
Atogepant + Verapamil
Severity: Moderate
Atogepant and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and may increase atogepant exposure, increasing the risk of adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 (and possibly intestinal transporters) raises atogepant concentrations.
What to do
Limit atogepant dose to the reduced dose recommended in labeling for chronic migraine prevention when used with moderate CYP3A4 inhibitors and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Verapamil?
MediHelp rates the interaction as moderate. Atogepant and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and may increase atogepant exposure, increasing the risk of adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant dose to the reduced dose recommended in labeling for chronic migraine prevention when used with moderate CYP3A4 inhibitors and monitor tolerability.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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