Drug interactions
Atogepant + Ziprasidone
Severity: Minor
Atogepant and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and ziprasidone is only a weak CYP3A4 inhibitor in vitro, so any rise in atogepant exposure is expected to be small. A clinically important interaction is unlikely.
What this interaction means in plain words
Atogepant and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by ziprasidone reducing atogepant metabolism.
What to do
No dose change is generally needed; be aware of adverse effects such as nausea, constipation and somnolence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Ziprasidone?
MediHelp rates the interaction as minor. Atogepant and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is a CYP3A4 substrate, and ziprasidone is only a weak CYP3A4 inhibitor in vitro, so any rise in atogepant exposure is expected to be small. A clinically important interaction is unlikely.
How serious is the interaction between Atogepant and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; be aware of adverse effects such as nausea, constipation and somnolence.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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