Drug interactions
Atomoxetine + Chlorpromazine
Severity: Moderate
Atomoxetine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combining them may add to the risk of torsades de pointes, especially with other risk factors. Atomoxetine can also raise heart rate and blood pressure, which is relevant in patients with cardiac disease.
What this interaction means in plain words
Atomoxetine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, mainly through cardiac potassium channel blockade by chlorpromazine with a smaller contribution from atomoxetine.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after dose changes, and consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Atomoxetine with Chlorpromazine?
MediHelp rates the interaction as moderate. Atomoxetine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and combining them may add to the risk of torsades de pointes, especially with other risk factors. Atomoxetine can also raise heart rate and blood pressure, which is relevant in patients with cardiac disease.
How serious is the interaction between Atomoxetine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after dose changes, and consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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