Drug interactions
Atomoxetine + Leuprolide
Severity: Moderate
Atomoxetine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and atomoxetine may add to this effect in susceptible patients. The clinical significance is generally modest but matters in those with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Atomoxetine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation, with leuprolide effect thought to arise from testosterone suppression altering cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and repeat if other QT-prolonging drugs are added or symptoms occur. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Atomoxetine with Leuprolide?
MediHelp rates the interaction as moderate. Atomoxetine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and atomoxetine may add to this effect in susceptible patients. The clinical significance is generally modest but matters in those with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Atomoxetine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat if other QT-prolonging drugs are added or symptoms occur. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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