Drug interactions
Atomoxetine + Rolapitant
Severity: Major
Atomoxetine and Rolapitant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine is mainly cleared by CYP2D6, and strong inhibition increases exposure several-fold. This may cause higher heart rate and blood pressure, insomnia, and other adverse effects.
What this interaction means in plain words
Atomoxetine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, markedly reducing atomoxetine clearance.
What to do
Monitor heart rate, blood pressure and tolerability, and reduce the atomoxetine dose as for strong CYP2D6 inhibitors if needed. Inhibition may last at least 28 days after rolapitant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
- Fosphenytoin + Rolapitant Major
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Rolapitant?
MediHelp rates the interaction as major. Atomoxetine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atomoxetine is mainly cleared by CYP2D6, and strong inhibition increases exposure several-fold. This may cause higher heart rate and blood pressure, insomnia, and other adverse effects.
How serious is the interaction between Atomoxetine and Rolapitant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and tolerability, and reduce the atomoxetine dose as for strong CYP2D6 inhibitors if needed. Inhibition may last at least 28 days after rolapitant.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Deutetrabenazine. The full list is on the Rolapitant page.
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