Drug reference
rolapitant
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Miscellaneous(GIT))
Mechanism of action
NK-1 receptors are highly concentrated in the vomiting center of the brain and bind a neurokinin termed substance P; activation of NK-1 receptors by substance P plays a central role in eliciting chemotherapy-induced nausea and vomiting. Blocking the interaction of substance P at the NK-1 receptor, NK-1 receptor antagonists improve the symptoms.
Common side effects
- Dyspepsia
- Decreased appetite
- Neutropenia
- Dizziness
- Urinary tract infection
Contraindications
- Coadministration with CYP2D6 substrates with a narrow therapeutic index (eg, thioridazine and pimozide) Hypersensitivity to any component of the product <2 years of age
Known interactions (1)
- colchicine + rolapitant Moderate
Related conditions
Frequently asked questions
What drug class is rolapitant?
rolapitant belongs to: Gastrointestinal Tract.
How does rolapitant work?
NK-1 receptors are highly concentrated in the vomiting center of the brain and bind a neurokinin termed substance P; activation of NK-1 receptors by substance P plays a central role in eliciting chemotherapy-induced nausea and vomiting. Blocking the interaction of substance P at the NK-1 receptor, NK-1 receptor antagonists improve the symptoms.
What are the common side effects of rolapitant?
Dyspepsia, Decreased appetite, Neutropenia, Dizziness, Urinary tract infection
Which drugs interact with rolapitant?
colchicine
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