Drug interactions
Deutetrabenazine + Rolapitant
Severity: Major
Deutetrabenazine and Rolapitant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a long-lasting CYP2D6 inhibitor that can substantially raise exposure to active deutetrabenazine metabolites. This increases the risk of QT prolongation, sedation, depression and parkinsonism.
What this interaction means in plain words
Deutetrabenazine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2D6 by rolapitant reduces metabolism of the active metabolites of deutetrabenazine.
What to do
Limit deutetrabenazine to no more than 36 mg/day (18 mg per dose). Remember that CYP2D6 inhibition by rolapitant persists for several weeks and monitor for QT prolongation and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
- Fosphenytoin + Rolapitant Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Rolapitant?
MediHelp rates the interaction as major. Deutetrabenazine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rolapitant is a long-lasting CYP2D6 inhibitor that can substantially raise exposure to active deutetrabenazine metabolites. This increases the risk of QT prolongation, sedation, depression and parkinsonism.
How serious is the interaction between Deutetrabenazine and Rolapitant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 36 mg/day (18 mg per dose). Remember that CYP2D6 inhibition by rolapitant persists for several weeks and monitor for QT prolongation and adverse effects.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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