Drug interactions
Rolapitant + Thioridazine
Severity: Contraindicated
Rolapitant and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant increases thioridazine concentrations, which may lead to QT prolongation and torsades de pointes. The CYP2D6 inhibition by rolapitant persists for days.
What this interaction means in plain words
Rolapitant and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rolapitant belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
Why it happens
Rolapitant inhibits CYP2D6, reducing thioridazine metabolism.
What to do
Do not use rolapitant in patients taking thioridazine; choose another antiemetic. The inhibition persists for at least 28 days after rolapitant.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
- Fosphenytoin + Rolapitant Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Rolapitant with Thioridazine?
MediHelp rates the interaction as contraindicated. Rolapitant and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rolapitant increases thioridazine concentrations, which may lead to QT prolongation and torsades de pointes. The CYP2D6 inhibition by rolapitant persists for days.
How serious is the interaction between Rolapitant and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use rolapitant in patients taking thioridazine; choose another antiemetic. The inhibition persists for at least 28 days after rolapitant.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Atomoxetine, Deutetrabenazine. The full list is on the Rolapitant page.
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