Drug interactions
Pimozide + Rolapitant
Severity: Contraindicated
Pimozide and Rolapitant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant increases pimozide concentrations, which may lead to QT prolongation and torsades de pointes. The effect of rolapitant on CYP2D6 is long-lasting, persisting for days after a dose.
What this interaction means in plain words
Pimozide and Rolapitant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing pimozide metabolism.
What to do
Do not use rolapitant with pimozide; choose another antiemetic regimen. The inhibition persists for at least 28 days after rolapitant.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rolapitant
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
- Fosphenytoin + Rolapitant Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Rolapitant?
MediHelp rates the interaction as contraindicated. Pimozide and Rolapitant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rolapitant increases pimozide concentrations, which may lead to QT prolongation and torsades de pointes. The effect of rolapitant on CYP2D6 is long-lasting, persisting for days after a dose.
How serious is the interaction between Pimozide and Rolapitant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use rolapitant with pimozide; choose another antiemetic regimen. The inhibition persists for at least 28 days after rolapitant.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Thioridazine, Atomoxetine, Deutetrabenazine. The full list is on the Rolapitant page.
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