Drug interactions
Eliglustat + Rolapitant
Severity: Major
Eliglustat and Rolapitant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is a CYP2D6 substrate with dose-dependent QT effects, and rolapitant's long-lasting CYP2D6 inhibition can raise its levels. This increases the risk of PR, QRS and QTc prolongation and arrhythmia.
What this interaction means in plain words
Eliglustat and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, markedly reducing eliglustat clearance.
What to do
Avoid the combination where possible, using an alternative antiemetic. If unavoidable, monitor ECG and consider eliglustat dose reduction per labeling for the patient's CYP2D6 status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Flecainide + Rolapitant Major
- Fosphenytoin + Rolapitant Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Rolapitant?
MediHelp rates the interaction as major. Eliglustat and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is a CYP2D6 substrate with dose-dependent QT effects, and rolapitant's long-lasting CYP2D6 inhibition can raise its levels. This increases the risk of PR, QRS and QTc prolongation and arrhythmia.
How serious is the interaction between Eliglustat and Rolapitant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using an alternative antiemetic. If unavoidable, monitor ECG and consider eliglustat dose reduction per labeling for the patient's CYP2D6 status.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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