Drug interactions
Atorvastatin + Digoxin
Severity: Moderate
Atorvastatin and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin, especially at high doses, can modestly increase digoxin exposure. The rise is usually small but may matter in patients with a narrow therapeutic margin or renal impairment.
What this interaction means in plain words
Atorvastatin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein by atorvastatin reduces intestinal and renal digoxin efflux.
What to do
Check digoxin levels when starting or changing the atorvastatin dose, particularly at higher doses. Monitor for nausea, visual changes and arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Digoxin?
MediHelp rates the interaction as moderate. Atorvastatin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atorvastatin, especially at high doses, can modestly increase digoxin exposure. The rise is usually small but may matter in patients with a narrow therapeutic margin or renal impairment.
How serious is the interaction between Atorvastatin and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin levels when starting or changing the atorvastatin dose, particularly at higher doses. Monitor for nausea, visual changes and arrhythmia.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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