Drug interactions
Atorvastatin + Fluconazole
Severity: Moderate
Atorvastatin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase atorvastatin exposure, raising the risk of myopathy and, rarely, rhabdomyolysis. The risk rises with higher statin doses, renal impairment and advanced age.
What this interaction means in plain words
Atorvastatin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of atorvastatin.
What to do
Use the lowest effective atorvastatin dose or temporarily suspend it during short fluconazole courses. Instruct patients to report muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Fluconazole?
MediHelp rates the interaction as moderate. Atorvastatin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can increase atorvastatin exposure, raising the risk of myopathy and, rarely, rhabdomyolysis. The risk rises with higher statin doses, renal impairment and advanced age.
How serious is the interaction between Atorvastatin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose or temporarily suspend it during short fluconazole courses. Instruct patients to report muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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