Drug interactions
Atorvastatin + Loratadine
Severity: Minor
Atorvastatin and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is a weak P-glycoprotein substrate/inhibitor and might slightly raise loratadine exposure. No meaningful clinical effect is expected given loratadine's wide therapeutic margin.
What this interaction means in plain words
Atorvastatin and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Loratadine belongs to Respiratory.
Why it happens
Theoretical P-glycoprotein inhibition; effect not clinically established.
What to do
No action is needed beyond routine awareness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atorvastatin and Loratadine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Loratadine?
MediHelp rates the interaction as minor. Atorvastatin and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is a weak P-glycoprotein substrate/inhibitor and might slightly raise loratadine exposure. No meaningful clinical effect is expected given loratadine's wide therapeutic margin.
How serious is the interaction between Atorvastatin and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine awareness.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
